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Die heilende Wirkung von KurkumaIn Indien wird Kurkuma seit Tausenden von Jahren als Heilmittel eingesetzt. Mittlerweile nutzen auch wir in Europa Kurkuma um unsere Gesundheit positiv zu beeinflussen.Kleinen wie den großen gesundheitlichen Problemen liegt ein Prinzip zugrunde: oxidativer Stress. Freie Radikale sind der Grund für den oxidativen Stress. Sie entstehen bei Stoffwechselvorgängen in jeder einzelnen Zelle im Körper und beschleunigen Krankheiten und den Alterungsprozess.Während unser Körper regeneriert sollte die Konzentration der freien Radikalen wieder absinken. Sollte - bei den meisten tut sie das nicht. Die Konzentration ist chronisch erhöht, wir leiden an oxidativem Stress.Die bioaktiv wirkenden Stoffe aus Kurkuma sind sehr starke Antioxidantien, das heißt, sie reduzieren den oxidativen Stress.Die Gelbwurzel wirkt entzündungshemmend und antibakteriell (Schwellungen, Beschwerden in Gelenken und Muskeln). Sie unterstützt die Leber und lindert Verdauungsbeschwerden. Auch Allergien wie Heuschnupfen kann Kurkumin positiv beeinflussen.Einsatzgebiete des Curcumin-Extraktes: Schmerzmittel und Entzündungshemmer Verbesserung der Gallen- und Leberfunktion Senkung des Cholesterinspiegels Kurbelt den Stoffwechsel an Kann beim Abnehmen helfen Senkung des Blutzuckers Krebserkrankungen (u.a. Brust-, Prostata- und Darmkrebs) Alzheimer-Krankheit Reizdarm-Symptom Rheumatische Arthritis Mukoviszidose (zystische Fibrose) Hepatitis-C Schutz der Herzkranzgefäße Menstruationsbeschwerden Blähungen, Völlegefühl und Bauchkneifen Zahnfleischentzündungen und weißere Zähne HeuschnupfenWarum der Kurkuma-Extrakt Curcugreen™ wirksamer istUm die wunderbare Heilwirkung von Kurkuma besser nutzbar zu machen wurde Curcugreen™ entwickelt. Die wirksamen Stoffe der Kurkuma-Pflanze werden auf eine besonders schonende Weise extrahiert und anschließend wieder auf spezielle Art zusammengefügt.Drei Stoffe aus der Kurkumawurzel sind für ihre heilende Wirkung verantwortlich: Curcumin (das gibt dem Pulver seine gelbe Farbe), Demethoxycurcumin und Bis-Demethoxycurcumin. Wenn man von allen drei auf einmal spricht, nennt man sie Curcuminoide. In der Pflanze kommen die Curcuminoide natürlicherweise gemeinsam mit ätherischen Ölen vor. Beim Trocknen des Kurkuma-Pulvers verflüchtigen die ätherischen Öle, übrig bleiben die Curcuminoide. Sie sind jedoch nicht wasserlöslich. Das ist ein Problem, denn der Körper kann sie daher nur schwer aufnehmen. In Curcugreen™ werden die ätherischen Öle gezielt aus der Pflanze extrahiert und anschließend dem getrockneten Pulver in einem speziellen Verfahren wieder zugesetzt. In dieser Kombination können die Curcuminoide viel besser vom Körper absorbiert und über den Dünndarm aufgenommen werden. Curcugreen™ hat eine sieben- bis neunfach höhere Wirkung als normales Kurkuma-Pulver.Curcugreen™ ist entzündungshemmend, lässt Virus- und Pilzinfektionen verschwinden, stärkt das Immunsystem und wirkt verbeugend gegen viele Volkskrankheiten.Curcugreen™ - 7-fach wirksamer als normales Curcumin: Dringt besser durch die Zellmembranen Hat eine bessere Bioverfügbarkeit Ist höher konzentriert im Blut Bleibt länger im Blutfor you high curcumaIn unseren veganen und laktosefreien Kurcuma-Kapseln haben wir einen der hochwertigsten Kurkuma-Extrakte verwendet. Curcugreen™ ist ein patentierter Rohstoff und macht unsere Kurkuma-Kapseln 7-fach wirksamer. Quellen & Studien zum Weiterlesen 1. Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. Br J Nutr. 2011 Oct; 106 Suppl 1: S198-2011. 2. A Randomized, Pilot study to assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phytotherapy Research 2012; OI:10.1002/ptr.4639 3. Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells. Integr Cancer Ther. 2013 Mar;12(2):145-52. Epub 2012 Apr 24. 4. A Pilot Clinical Trial of Radioprotective Effects of Curcumin Supplementation in Patients with Prostate Cancer. Hejazi et al., J Cancer Sci Ther 2013, 5. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis Molecular medicine reports, 2013 6. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res. 2014 Apr;28(4):579-85. 7. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014;167:368-75. 8. Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT. PLoS ONE 9(9): e107514. 9. Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures. PLoS ONE 9(1): e85397. 10. Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. BMC Cancer. 2015 Apr 10;15:250. Weiterlesen 11. Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. Cancer Prev Res (Phila). 2015 May;8(5):431-43. 12. Curcumin and major depression: A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. European Neuropsychopharmacology , Volume 25 , Issue 1 , 38 – 50 13. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 2015 Mar;36(3):355-67. 14. BCM-95 and (2-hydroxypropyl)-ß-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts. Hum Mol Genet. 2015 Apr 29. 15. Evaluation of antidepressant like activity of Curcumin and its combination with Fluoxetine and Imipramine: An acute and chronic study, Acta poloniae pharmaceutica ñ drug research, vol. 68 no. 5 pp. 769-775, 2011 16. The use of an anti-inflammatory supplement in patients with chronic kidney disease 17. Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression 18. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95®CG (Biocurcumax™), A Novel Bioenhanced Preparation of Curcumin, Indian J Pharm Sci 2008;70(4):445-449 19. 6-month double-blind, placebo-controlled, pilot clinical trial of curcumin in patients with Alzheimer’s disease, J Clin Psychopharmacol, 2008, 28:110-113 20. Curcumin effects on Blood Lipid profile in a 6-month human Study, Pharmacological Research 56 (2007) pg 509-514 21. Bioavailability of BiocurcumaxTM (BCM-095TM), Spice India 2006 (Sept);11-15 22. Enhancing the Absorption of Curcuminoids, Spice India 2005(July); 23-26 23. Effect of a topical curcumin preparation (BIOCURCUMAX) on burn wound healing in rats, Journal of Pharmaceutical and Biomedical Sciences (JPBMS), Vol. 08, Issue 08 24. The Effect of Exercise and Nutritional Supplementation on Proinflammatory Cytokine Expression in Young Racehorses During Training, J Equine Vet Sci. 2012 December;32(12):805-15 25. Evaluation of Antiepileptic and Memory Retention Activity of Curcumin Per SE and in Combination with Antiepileptic Drugs, Asian J Pharm Clin Res. 2014;6(2):145-148 26. Anti-inflammatory activity of BCM-95 (bio-enhanced formulation of turmeric with increased bioavailabilty) compared to Curcumin in Wistar rats, Pharmacognosy Journal, Vol 8, Issue 4, Jul-Aug, 2016 380 -384 27. Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation, MOLECULAR MEDICINE REPORTS 13: 592-604, 2016 28. Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults, British Journal of Nutrition, Volume 115, Issue 12, June 2016, pp. 2106-2113 29. Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study; Hejazi J, Rastmanesh R, Taleban FA, Molana SH, Hejazi E, Ehtejab G, Hara N; Nutr Cancer. 2016;68(1):77-85. doi: 10.1080/01635581.2016.1115527. 30. A randomized double-blind placebo-controlled phase IIB trial of curcumin in oral leukoplakia, DOI: 10.1158/1940-6207.CAPR-15-0390 Published 7 June 2016 31. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study, European Journal of Physical and Rehabilitation Medicine [2016, 52(3):321-330] 32. Short Report of a Preliminary Open Study of Synofit-Containing Bio-Curcumin, Greenlipped Mussel and Blackcurrant Leaf Extract in Arthritis, Open Journal of Rheumatology and Autoimmune Diseases, 5, 113-117. doi: 10.4236/ojra.2015.54018. 33. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Lopresti AL, Drummond PD, J Affect Disord. 2017; 207:188-196. doi: 10.1016/j.jad.2016.09.047. 34. Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood. J Transl Med. 2017 Oct 20;15(1):213. doi: 10.1186/s12967-017-1315-4. 35. Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice; Metab Brain Dis, DOI 10.1007/s11011-017-0133-y 36. Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells. Molecular Carcinogenesis. 2017; 56:2446–2460. 37. Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis, Scientific Reportsvolume 7, Article number: 814 (2017) 38. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study, BMC Complementary and Alternative Medicine, 2018 18:7 39. Suppression of Proliferation and Invasive Behavior of Human Metastatic Breast Cancer Cells by Dietary Supplement BreastDefend. J Jiang, R Wojnowski, A Jedinak… - Integrative Cancer Therapies 10(2) 192–200(2011) 40. Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaidTM: Mechanism of activity. Jia hua Jiang, Isaac Eliaz and Dani el Sliva international journal of oncology 38: 1675-1682, 2011 41. ProstaCaid Induces G2/M Cell Cycle Arrest and Apoptosis in Human and Mouse Androgen– Dependent and – Independent Prostate Cancer Cells. Integrative Cancer Therapies 9(2) 186–196 42. Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model. J Funct Foods. 2010;2(1):60–5 43. Clinical Evaluation Of A Herbal Formulation, Rhulief™, In The Management Of Knee Osteoarthritis. Osteoarthritis And Cartilage. 2011 Sep 1;19:S145-6 44. Effect of Biocurcumax TM Curcumin (BCM-95) On Treatment of Moderate Chronic Periodontitis. Journal of Mazandaran University of Medical Sciences. 2018 Mar 15;27(158):45-55. 45. Oral Bioavailability of BCM-95® in Dogs” Poster presentation. 2009 ACVIM Forum/ Canadian VMA Convention: June 3-6, 2009;Montréal, Québec, Canada 46. 46a. Evaluation of Hepatoprotective activity of combination of phyllanthusniruri and Curcuma longa extracts in Wistar rats. Res. J. Pharm., Biol. Chem. Sci. 2012:1260-1268 46.b. Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts against ethanol induced toxicity in wistar rats. International Journal of Pharma and Bio Sciences. 2016;7(1):P12-8. 46.c. Evaluation Of Hepatoprotective Activity Of Combination Of Phyllanthus Niruri And Curcuma Longa Extracts In Wistar Rats. (POSTER) 47. Curcumin Inhibits Polycomb Repressive Complex 2 through lncRNA-PVT1 and Enhances Gemcitabine Sensitivity in Chemoresistant Pancreatic Cancer. Gastroenterology. 2016 Apr 1;150(4):S624. 48. Impact of a 3-weeks randomized double-blind cross-over study curuminoid supplementation on endotoxemia, inflammatory markers, and lipid profiles in healthy overweight and obese adults. Proceedings of the Nutrition Society. 2016;75(OCE3). 49. Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling. International journal of oncology. 2015 Dec 1;47(6):2064-72. 50. ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer. International journal of oncology. 2012 May 1;40(5):1339-44. 51. BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer. Oncology reports. 2012 Oct 1;28(4):1139-45. 52. Curcumin supplementation mitigates NASH development and progression in female Wistar rats. Physiological reports. 2018 Jul;6(14):e13789. 53. Role of curcumin as an adjuvant in treatment of advanced head and neck squamous cell carcinoma. Int J Otorhinolaryngol Head Neck Surg 2018;4:1388-93 requirejs(['jquery'],function($){ $('#toggle-sources').click(function(){ $(this).next().slideToggle(); }); });

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Brucella:Molecular & Cell Biol
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Brucella:Molecular & Cell Biol ab 73.99 EURO

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Botanical and in vitro studies on Echinacea pur...
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Some of the published Research: 1. Rabie, Kawther A.E., M. Abderassoul and H.H. Manaf (2007). Infuence of culutre conditions on biomass formation in callus culture of Echinacea purpurea. J. Agric. Sci. Mansoura Univ., 32 (8): 6249-6257. 2. Manaf, H.H. (2008). The role of potassium nitrate in alleviating detrimental effects of salt stress of soybean roots in vitro. J. Biol. Chem. Environ. Sci., 3 (4): 363-380. 3. Manaf, H.H., Kawthar A.E. Rabie and Mona S. Abd El-Aal (2009). In vito callus formation and plant regeneration of Silybum marianum (L.) Gaertn. Annals of Agric. Sci., 54 (2): 283-289. 4. Kawthar A.E. Rabie, Mona S. Abd El-Aal and Manaf, H.H. (2010). Enhanced silymarin accumulation as influence of medium composition in cell suspension cultures of Silybum marianum (L.) Gaertn. J. of plant production, Mansoura Univ., 1 (2): 319-332. 5. Kawthar, A. Rabie, H.H. Manaf, Hasnaa, A.H. Gouda and I.M. Shahat (2010). Influence of compost and rock amendments on growth and active ingredients of safflower (Carthamus tinctorius L.). Australian J. of Basic and Applied Sci. 4 (7): 1626-1631.

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Onlinebestimmung des Sauergehaltes beim Life-Ce...
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Ausgangspunkt für die Arbeit war die Aufgabe zur Entwicklung eines Messverfahrens zur Onlinebestimmung des Sauerstoffgehaltes in der Zellkultur beim Life Cell Imaging. Sie beinhalt die Grundlagen, die zur Lösung der Fragestellung nötig waren. Dazu zählen u. a. die Auswahl des zu nutzenden Sensors, die Messwerterfassung, die Software zur Entwicklung der Programme und die Erfassung der biol. und physikal. Vorgänge. Anschließend musste geklärt werden, welche Geräte zum Einsatz kommen sollten und wie diese im Zusammenhang stehen. Mit Hilfe von Regeleinrichtungen wurde eine Gasmischeinheit konstruiert, mit der sich beliebige Gasmischungen aus Sauerstoff, Kohlenstoffdioxid und Stickstoff herstellen lassen. Es wurde ein Programm konzipiert, mit dem sich auf der einen Seite die vom Sensor ausgegeben Werte aufnehmen lassen und auf der anderen Seite die Begasung individuell einstellen lässt. Die Umsetzung erfolgte durch den Einsatz der Software LabVIEW. Nach Programmerstellung und Begasungseinstellung, wurden Untersuchungen an Zellen unter einem Mikroskop durchgeführt. Diese sollten das Zusammenspiel der einzelnen Komponenten, wie Begasungseinheit, Messcomputer und Sensoren, zeigen.

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Cellular Therapy
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The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stern cell transplantation, including the ex vivo expansion of hematopoietic stern cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also re sult in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biol ogy, the identification of hematopoietic, mesenchymal and neuronal stern cells, together with breakthroughs in the methodology for isolat ing, purifying, expanding, and storing human cells could make cellular therapy an alternative to organ transplantation in certain diseases within the next decade. Placental blood may be the source of choice in isolating naive progenitor cells for allogeneic transplantation. Immunotherapy is the most hopeful strategy to date for the treat ment of tumors resistant to chemotherapy, radiation therapy, or hor mone therapy. It includes the use of tumor-infiltrating lymphocytes, ex vivo activated memory T lymphocytes, and cell-based vaccines.

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Plant Biotechnology for Sustainable Production ...
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This book is a collection of chapters concerning the use of biomass for the sustainable production of energy and chemicals-an important goal that will help decrease the production of greenhouse gases to help mitigate global warming, provide energy security in the face of dwindling petroleum reserves, improve balance of payment problems and spur local economic development. Clearly there are ways to save energy that need to be encouraged more. These include more use of energy sources such as, among others, manure in anaerobic digesters, waste wood in forests as fuel or feedstock for cellulosic ethanol, and conservation reserve program (CRP) land crops that are presently unused in the US. The use of biofuels is not new, Rudolf Diesel used peanut oil as fuel in the ?rst engines he developed (Chap. 8), and ethanol was used in the early 1900s in the US as automobile fuel [Songstad et al. (2009) Historical perspective of biofuels: learning from the past to rediscover the future. In Vitro Cell Dev Biol Plant 45:189-192). Brazil now produces enough sugar cane ethanol to make up about 50% of its transportation fuel needs (Chap. 4). The next big thing will be cellulosic ethanol. At present, there is also the use of Miscanthus x giganteous as fuel for power plants in the UK (Chap. 2), bagasse (sugar cane waste) to power sugar cane mills (Chap. 4), and waste wood and sawdust to power sawmills (Chap. 7).

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Histological Typing of Tumours of the Central N...
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Although more than 12 years have passed since publication of the first WHO histological classification of central nervous system (CNS) tumours, the changes in this revised edition are not radical. Only one formerly recognized entity has been deleted: the monstrocellular sarcoma, because there is immuno cytochemical evidence of its astrocytic nature. Several new tumour types have been added: the pleomorphic xanthoastro cytoma has been generally acknowledged for almost a decade, the neurocytoma has gradually evolved as a clinical-pathological entity, and two new entries, the dysembryoplastic neuroepi thelial tumour and the desmoplastic infantile ganglioglioma, have only been characterized morphologically during the past few years. We regard the classification as an international standard to facilitate communication and have tried to avoid current con ceptual controversies. The majority of partiCipants supported inclusion of the term "primitive neuroectodermal tumour" (pNET). However, because of our limited knowledge of the biol ogy of embryonal CNS tumours, preference was given to use PNET selectively, rather than applying it to all small cell embryo nal childhood tumours, irrespective of their histological pheno type. Ependymomas and meningiomas now have new histological SUbtypes. Most of these are not associated with biological behaviour different from the parent tumour type, but their description will aid the practising pathologist to identify and classify these lesions. 2 Introduction Histological Typing Following the philosophy of this WHO series, classification is based primarily on histological assessment of cell types and tis sue patterns recognized by conventional light microscopy.

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Papillomaviruses and Human Disease
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In recent years, papillomaviruses in general and human papillo maviruses in particular have been recognized as possible agents of important diseases, including some forms of human cancer. The purpose of this book is to present a concise panorama of the pre sent status of knowledge of this topic. This knowledge is as impor tant to molecular biologists and virologists as it is to clinicians and pathologists. To bridge the gap among these diverse groups of investigators, we conceived of a book covering a broad spectrum of the basic scientific, clinical, and pathological aspects of diseases associated with papillomaviruses. Although the principal thrust of this book is directed at human papillomaviruses, fundamental knowledge of animal viruses is essential to the current understand ing of the molecular mechanisms of cell transformation. For this reason, a chapter on animal viruses has also been included. Some of the experimental work having to do with the elucidation of transformation and other aspects of interaction between the virus and the cell cannot be based on human papillomaviruses because of a lack of suitable experimental models. Hence, some of the chapters dealing with fundamental aspects of viral molecular biol ogy are based on animal models. We were very fortunate in having persuaded a number of distin guished colleagues to contribute to this work.

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Testicular Function: From Gene Expression to Ge...
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This volume contains the text of the main lectures given by interna tionally recognized scientists at the Tenth European Workshop on Mo lecular and Cellular Endocrinology of the Testis, held in Capri, Italy, from 28 March to 1 April 1998. Topics include spermatogonial transplantation, germ stem cell biol ogy, regulation of meiosis and spermiogenesis, growth factors, cell sig naling and transduction, steroidogenesis, androgen-regulated genes, sperm activation and sperm factors active at fertilization and the mo lecular basis of specific pathologies of the testis. Looking back at the previous 'Capri edition' (1986), the lectures of which were published by Elsevier, it is perhaps not surprising to notice that many of the top ics addressed at that time are basically the same now. On the other hand, it appears evident that the search for experimental models of sig nificant physiological value to study testicular function has advanced greatly. In this connection, the use of genetically manipulated animal models in the study of the regulation of spermatogenesis and of the en docrine role of the testis represents a core part of the present volume. The authors deserve our special thanks not only for delivering ex cellent state-of-the-art lectures, but also for providing their manuscripts well before the meeting.

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