Erscheinungsdatum: 07.01.1999, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Plant Biochemistry Molecular Biol 2e, Auflage: 2. Auflage von 1999 // 2. Auflage, Autor: Lea, Verlag: John Wiley & Sons, Sprache: Englisch, Schlagworte: SCIENCE // Life Sciences // Biochemistry, Rubrik: Biochemie // Biophysik, Seiten: 388, Informationen: Paperback, Gewicht: 749 gr, Verkäufer: averdo
High Quality Content by WIKIPEDIA articles! A pharmacophore was first defined by Paul Ehrlich in 1909 as "a molecular framework that carries (phoros) the essential features responsible for a drug?s (=pharmacon's) biological activity" (Ehrlich. Dtsch. Chem. Ges. 1909, 42: p.17). In 1977, this definition was updated by Peter Gund to "a set of structural features in a molecule that is recognized at a receptor site and is responsible for that molecule's biological activity" (Gund. Prog. Mol. Subcell. Biol. 1977, 5: pp 117?143). The IUPAC definition of a pharmacophore is "an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target and to trigger (or block) its biological response".
In recent years, papillomaviruses in general and human papillo maviruses in particular have been recognized as possible agents of important diseases, including some forms of human cancer. The purpose of this book is to present a concise panorama of the pre sent status of knowledge of this topic. This knowledge is as impor tant to molecular biologists and virologists as it is to clinicians and pathologists. To bridge the gap among these diverse groups of investigators, we conceived of a book covering a broad spectrum of the basic scientific, clinical, and pathological aspects of diseases associated with papillomaviruses. Although the principal thrust of this book is directed at human papillomaviruses, fundamental knowledge of animal viruses is essential to the current understand ing of the molecular mechanisms of cell transformation. For this reason, a chapter on animal viruses has also been included. Some of the experimental work having to do with the elucidation of transformation and other aspects of interaction between the virus and the cell cannot be based on human papillomaviruses because of a lack of suitable experimental models. Hence, some of the chapters dealing with fundamental aspects of viral molecular biol ogy are based on animal models. We were very fortunate in having persuaded a number of distin guished colleagues to contribute to this work.
The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stern cell transplantation, including the ex vivo expansion of hematopoietic stern cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also re sult in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biol ogy, the identification of hematopoietic, mesenchymal and neuronal stern cells, together with breakthroughs in the methodology for isolat ing, purifying, expanding, and storing human cells could make cellular therapy an alternative to organ transplantation in certain diseases within the next decade. Placental blood may be the source of choice in isolating naive progenitor cells for allogeneic transplantation. Immunotherapy is the most hopeful strategy to date for the treat ment of tumors resistant to chemotherapy, radiation therapy, or hor mone therapy. It includes the use of tumor-infiltrating lymphocytes, ex vivo activated memory T lymphocytes, and cell-based vaccines.
In keeping with goal and style of the Handbook in Modern Biophysics series, the proposed book will maintain a chapter structure that contains two parts: concepts and biological application. The book also integrates all the chapters into a smooth, continuous discourse. The first and second chapters establish the mathematical methods and theoretical framework underpinning the different topics in the rest if the book. Other chapters will use the theoretical framework as a basis to discuss optical and NMR approaches. Each chapter will contain innovative didactic elements that facilitate teaching, self-study, and research preparation (key points, summary, exercise, references). HANDBOOK OF MODERN BIOPHYSICSSeries Editor Thomas Jue, PhDHandbook of Modern Biophysics brings current biophysics topics into focus, so that biol-ogy, medical, engineering, mathematics, and physical-science students or researchers can learn fun damental concepts and the application of new techniques in addressing biomedical challenges. Chapters explicate the conceptual framework of the physics formalism and illustrate the biomedical applica tions. With the addition of problem sets, guides to further study, and references, the interested reader can continue to independently explore the ideas presented.Volume III: Biomedical Applications of BiophysicsEditor: Thomas Jue, PhDIn Biomedical Applications of Biophysics, leading scholars present key topics pertinent to biomedical research: Protein Structure Prediction Molecular Modeling of Biomembranes: A How-To Approach Introduction to Electron Paramagnetic Resonance Spectroscopy Theory and Applications of Biomolecular NMR Spectroscopy FRET and Its Biological Application as a Molecular Ruler Introduction to Modern Techniques of Mass Spectrometry Transmission Electron Microscopy And Computer-Aided Image Processing For 3d Structural Analysis Of Macromolecules Raman Spectroscopy of Living CellsAbout the EditorThomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California Davis. He is an internationally recognized expert in develop-ing and applying magnetic resonance techniques to study animal as well as human physi-ology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regu-lation, exercise, and marine biology. As the Chair of the Biophysics Graduate Group Program at University of California Davis, he launched an initiative to establish a biophysics book series that will balance the physical-science/mathematics formalism with the biomedical perspective in order to develop an attractive education curriculum at the interface of physical science, engineering, mathematics, biology, and medicine. The Handbook of Modern Biophysics represents part of that curriculum development effort.
This widely-praised textbook is particularly suited for advanced undergraduates or graduates in chemistry, biochemistry, medicinal chemistry, and pharmacology. The third edition has been substantially revised to reflect new research in the field, and features a major new chapter on self-assembly, auto-organization, and molecular devices. The outstanding figures remain a highlight of the book, and were described in an earlier edition as "the best I've seen for showing the organic chemistry of biomolecules." (Quart. Rev. Biol.)
The 11th Hour Series of revision guides have been designed for quick reference.The organisation of these books will involve students actively in the learning process and reinforcement of concepts. At the end of each chapter there will be a test including multiple choice questions, true/false questions and short answer questions, every answer will involve an explanation. Each book will contain icons in the text indicating additional support on a dedicated web-page. Students having difficulties with their courses will find this an excellent way to raise their grades.